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Fatigue in Mesothelioma Patients

Eden Alii asked:




The word fatigue means the shortage or absence of energy that override the capability of mesothelioma patients to function and can result to mental disorder. Fatigue symptoms are weakness, exhaustion, extreme tiredness, weariness, etc. There could be psychological and emotional symptoms also in addition to the above mentioned. Mesothelioma patients may suffer from acute or chronic fatigue.

Acute fatigue usually have symptoms which begins and ends very quickly, and such symptoms are usually short-lived. Chronic fatigue symptoms usually stays for a long period.

Fatigue are seen in large portion in mesothelioma patients and those who had mesothelioma cancers in the past, or which may be as a result of other cancer-related factors. Some of the common factors are pain, medications, diet, weight loss, difficulties in breathing, insomia, anemia, flunctuating hormones, and tumors.

Emotional depression may also result in fatigue. Other factors are anxiety, and distress which comes either from direct result of mesothelioma treatments, the mesothelioma cancers, or as a result of psychological effects directed to the diagnosis of the mesothelioma cancers and the mesothelioma treatments used.get more info …

Fatigue may also come from mesothelioma treatments, like radiation therapy or chemotherapy. A high degree of energy from the body is required in radiation therapy to repair tissue, that can expend or use up the energy supply of the body. Fatigue may also come from the effect of chemotherapy, where the patient can suffer from nausea, vomiting and loss of weight, and reoccuring fatigue as a result. Poor appetite or dietery factors may also cause fatigue as the cancer may require the body to need more nutrients. The patient may not be feeding well so as to get the essential nutrients, which could be as a result of the cancer, or other cancer-related reasons…



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Pain Relief Delivered Across The Skin

Bruce Wilson asked:


Delivering any medicine into the body has its challenges and drawbacks. Medicines taken orally have taste problems and some people have difficulty swallowing. Nausea, vomiting and diarrhoea are possible side effects for almost any medication taken by mouth. Suppositories although effective are highly unpopular and are usually considered only as a last resort. Injections often induce a fear factor and cause at least some pain. Also a certain amount of skill needs to be required by the person administering the injection. If a medication can be applied to the skin and if it can cross the barrier of the skin most of these problems can be solved.

Transdermal formulations such as patches, creams and gels are able to carry medication across the skin and offer an alternative method of treatment. Patches that contain an accurate measured dose are most commonly used for carrying estrogen or testosterone as hormone replacement therapy. Nicotine replacement therapy patches are well known to help people stop smoking. There is also a potent medicine called scopolamine that is applied in patch form for treating sea sickness. A powerful opiate, for severe pain, called Fentanyl is also available in a patch.

A number of substances have gathered interest for their ability to carry drugs with them across the barrier of the skin and into the body. Dimethyl sulfoxide or DMSO as it is more commonly known is one such chemical with this ability. Grapeseed oil which is high in linoleic acid has this transdermal property. The Australian Emu produces an oil, also high in linoleic acid that acts as a medicine carrier as well as having anti-inflammatory properties and has become popular for those seeking to treat aches and pains.

There are a number of non steroidal anti-inflammatory drugs (NSAIDs) that are suitable for use in a transdermal base. The main disadvantage of NSAIDs is that they tend to cause stomach irritation when taken orally and if use is prolonged may lead to gastric bleeding. Applying a NSAID medicine to the skin has the benefit of being able to bypass the stomach and also allows the user to target the painful area. Stomach problems with transdermal use of this class of medicines become almost non existent.

NSAIDs such as Ketoprofen, Ibuprofen and Diclofenac are all available in transdermal gel formulations. Oruvail gel contains ketoprofen while Nurofen Gel contains ibuprofen. Voltaren Emulgel contains Diclofenac and is the most popular brand due to it having a longer lasting action. Diclofenac is for most people the NSAID of choice due to its long duration of activity and effectiveness.

Transdermal pain gels are used to treat the pain and inflammation of joint and muscle pain. These gels may be used for local application for inflamed tendons, ligaments, muscles and joints due to trauma, soft tissue rheumatism and localised rheumatic diseases. In practice there is usually little concern regarding side effects unless one has an allergy to any of the ingredients.

Application of diclofenac gel consists of gently rubbing in a small amount to the swollen or painful area two to three times daily. There is no greasy residue or staining involved and shortly after application there is nothing to see on the skin after the product has been rubbed in. Many users notice a slight cooling effect after application.

Transdermal gels will find a place for those that have difficulty in swallowing medicines or for those that suffer stomach related side effects from taking NSAIDs.



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