Best Antidepressants
Max Bellamy asked:
Although no Antidepressant is ideal, St. John’s wort (Hypericum perforatum L.) extract has proved its Antidepressant efficacy to the market that encourages effectiveness. It is a medicinal herb of centuries-old therapeutic stand, and has been named “arnica of the nerves” because of its therapeutic benefit to the nervous diseases. Its benefit of improving mood and quality of sleep are the reasons for its use in mild to moderate depression.
The chemical constituents that may be responsible for the safe Antidepressant action of this widely used Antidepressant are hypericin, pseudohypericin, hyperforin, naphtodianthrones, flavonoids, phenylpropanes, biflavones, terpene and sesquiterpene oils, tannins, xanthones, phloroglucinols, and essential oils. Many of the pharmacological activities appear to be present because of the presence of hypericin and flavonoid constituents.
St. John’s wort inhibits the re-uptake of serotonin, noradrenaline, and dopamine. It also inhibits monoamine oxidase (MAO), a complex enzyme system that metabolizes excess serotonin and epinephrine. This interference with the re-uptake of neurotransmitters and inhibition of MAO is believed to underline its Antidepressant activity.
An evidence of its efficiency and safety was presented by a meta-analysis that included 23 randomized trials and concluded that, in efficiency, St. John’s wort is superior to placebo and is comparable to TCAs and SSRIs. Also, it has lower rates of adverse events as compared to its competition.
The most commonly associated side effects with the use of St. John’s wort include fatigue, sedation, restlessness, anxiety, headache, dizziness, dry mouth, gastrointestinal symptoms, and skin reactions. Its side effects portray it as one of the safest available Antidepressant option.
St. John’s wort is thus a widely used, natural, effective and safe option to depress depression.
Taking Tramadol
Although no Antidepressant is ideal, St. John’s wort (Hypericum perforatum L.) extract has proved its Antidepressant efficacy to the market that encourages effectiveness. It is a medicinal herb of centuries-old therapeutic stand, and has been named “arnica of the nerves” because of its therapeutic benefit to the nervous diseases. Its benefit of improving mood and quality of sleep are the reasons for its use in mild to moderate depression.
The chemical constituents that may be responsible for the safe Antidepressant action of this widely used Antidepressant are hypericin, pseudohypericin, hyperforin, naphtodianthrones, flavonoids, phenylpropanes, biflavones, terpene and sesquiterpene oils, tannins, xanthones, phloroglucinols, and essential oils. Many of the pharmacological activities appear to be present because of the presence of hypericin and flavonoid constituents.
St. John’s wort inhibits the re-uptake of serotonin, noradrenaline, and dopamine. It also inhibits monoamine oxidase (MAO), a complex enzyme system that metabolizes excess serotonin and epinephrine. This interference with the re-uptake of neurotransmitters and inhibition of MAO is believed to underline its Antidepressant activity.
An evidence of its efficiency and safety was presented by a meta-analysis that included 23 randomized trials and concluded that, in efficiency, St. John’s wort is superior to placebo and is comparable to TCAs and SSRIs. Also, it has lower rates of adverse events as compared to its competition.
The most commonly associated side effects with the use of St. John’s wort include fatigue, sedation, restlessness, anxiety, headache, dizziness, dry mouth, gastrointestinal symptoms, and skin reactions. Its side effects portray it as one of the safest available Antidepressant option.
St. John’s wort is thus a widely used, natural, effective and safe option to depress depression.
Taking Tramadol
Tags: Antidepressant Activity, Gastrointestinal Symptoms
Antidepressants and High Blood Pressure – The Connection
Pauline Go asked:
Certain medications, drugs, supplements and other substances can elevate or worsen blood pressure or interfere with the actions of medications you are taking to control hypertension. Some specific antidepressants have been linked to increase or worsening the already existing high blood pressure in a patient.
Anti-depressants are class of drugs that are usually taken to treat depression, bipolar disorder or mood-related disorder. These drugs work primarily by changing the levels of certain chemicals (serotonin and dopamine) in the brain and nervous system. These chemicals regulate and co-ordinate interactions between different region of brain. Nowadays anti-depressants are increasingly used to treat variety of medical conditions and disorder besides depressive disorder. Serotonin and dopamine, however, play important roles in many parts of the body outside the nervous system. Both these compounds tend to affect heart and blood vessels, and anti-depressants drugs are designed to increase the available levels of these chemicals in the body. In concentrated amount, dopamine is also used as an emergency drug to increase blood pressure and heart rate during surgery and certain conditions where the blood pressure falls below the normal blood pressure i.e. 120/80 mm Hg. To some extent, serotonin too has similar blood-pressure raising effect and may increase the arterial blood-pressure.
Specific anti-depressants that are linked to increased blood pressure in the body include Buproprion, Venlafaxine (brand name Effexor), phenelzine(sold as Nardil). Combining tri-cyclic antidepressants with clonidine (catapers) may lead to dangerous elevations in blood pressure and heart beats because tri-cyclic anti-depressants inhibit the anti-hypertensive effect of clonidine.
So, if you have high blood pressure, you can still use anti-depressants with no problems but some may require little adjustments to their high blood pressure protocols. Your doctor or physician may choose to avoid certain anti-depressants and try-cyclic anti-depressants that elevate blood pressure.
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Certain medications, drugs, supplements and other substances can elevate or worsen blood pressure or interfere with the actions of medications you are taking to control hypertension. Some specific antidepressants have been linked to increase or worsening the already existing high blood pressure in a patient.
Anti-depressants are class of drugs that are usually taken to treat depression, bipolar disorder or mood-related disorder. These drugs work primarily by changing the levels of certain chemicals (serotonin and dopamine) in the brain and nervous system. These chemicals regulate and co-ordinate interactions between different region of brain. Nowadays anti-depressants are increasingly used to treat variety of medical conditions and disorder besides depressive disorder. Serotonin and dopamine, however, play important roles in many parts of the body outside the nervous system. Both these compounds tend to affect heart and blood vessels, and anti-depressants drugs are designed to increase the available levels of these chemicals in the body. In concentrated amount, dopamine is also used as an emergency drug to increase blood pressure and heart rate during surgery and certain conditions where the blood pressure falls below the normal blood pressure i.e. 120/80 mm Hg. To some extent, serotonin too has similar blood-pressure raising effect and may increase the arterial blood-pressure.
Specific anti-depressants that are linked to increased blood pressure in the body include Buproprion, Venlafaxine (brand name Effexor), phenelzine(sold as Nardil). Combining tri-cyclic antidepressants with clonidine (catapers) may lead to dangerous elevations in blood pressure and heart beats because tri-cyclic anti-depressants inhibit the anti-hypertensive effect of clonidine.
So, if you have high blood pressure, you can still use anti-depressants with no problems but some may require little adjustments to their high blood pressure protocols. Your doctor or physician may choose to avoid certain anti-depressants and try-cyclic anti-depressants that elevate blood pressure.
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